The 63 revised full papers of the main conference presented together with 85 revised workshop papers were carefully reviewed and selected from over 250 initial submissions. The papers are organized in topical sections on parallel/distributed architectures and mobile computing, numerical algorithms and parallel numerics, parallel and distributed non-numerical algorithms, environments and tools for as well as applications of parallel/distributed/grid computing, evolutionary computing, meta-heuristics and neural networks. The volume proceeds with the outcome of 11 workshops and minisymposia dealing with novel data formats and algorithms for dense linear algebra computations, combinatorial tools for parallel sparse matrix computations, grid applications and middleware, large scale computations on grids, models, algorithms and methodologies for grid-enabled computing environments, scheduling for parallel computing, language-based parallel programming models, performance evaluation of parallel applications on large-scale systems, parallel computational biology, high performance computing for engineering applications, and the minisymposium on interval analysis.