Narcos Over the Border is divided into three sections: narco-opposing force (NARCO OPFOR) organization and technology use; patterns of violence and corruption and the illicit economy; and United States response strategies. The work also includes short introductory essays, a strategic threat overview, an afterword and selected references. Specific topics covered include: advanced weaponry, internet use, kidnappings and assassinations, torture, beheadings, and occultism, cartel and gang evolutionary patterns, drug trafficking, street taxation, corruption, and border firefights.

This book was published as a special issue of Small Wars and Insurgencies.