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Autor(en): 
  • Stefania Averaimo
  • Intracellular ion channel 1 between neurogenesis and neurodegeneration: CLIC1 in neuronal physiology and pathology 
     

    (Buch)
    Dieser Artikel gilt, aufgrund seiner Grösse, beim Versand als 2 Artikel!


    Übersicht

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    Lieferstatus:   i.d.R. innert 5-10 Tagen versandfertig
    Veröffentlichung:  Juli 2014  
    Genre:  Naturwissensch., Medizin, Technik 
    ISBN:  9783639718980 
    EAN-Code: 
    9783639718980 
    Verlag:  Scholars' Press 
    Einband:  Kartoniert  
    Sprache:  English  
    Dimensionen:  H 220 mm / B 150 mm / D 8 mm 
    Gewicht:  215 gr 
    Seiten:  132 
    Zus. Info:  Paperback 
    Bewertung: Titel bewerten / Meinung schreiben
    Inhalt:
    The ¿cell cycle hypothesis¿ for neurodegenerative diseases suggests a link between "cell cycle-like reactivation" and neuronal death, mainly in Alzheimer disease (AD), one of the most common neurodegenerative diseases for which an efficient treatment is yet to be identified. The ¿insult¿ represented by A¿ deposits, a typical hallmark of AD, could force the neuron to re-enter the cell cycle. However, a highly differentiated cell unable to successfully accomplish a task normally attributable to immature cells, would end up in neuronal death. Considering neurodegeneration as a result of the abnormal activation in mature cells of a pathway that is typical of immature cells, the results shown in this book propose CLIC1 as part of this pathway, physiological and ¿successful¿ in immature cells, contributing to mantain growth cone morphology and sustaining axon outgrowth modulated by cAMP via PKA, but leading to cell death in ¿mature¿ neurons. Increased CLIC1 expression in the gangliar layer in AD mouse models before cognitive symptoms, proposes it as an early marker of AD. This study suggests a double role of CLIC1, in retinal ganglion cells physiology and pathology.

      



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