This book reports on research on innovative human systems integration and human-machine interaction, with an emphasis on artificial intelligence and automation, as well as computational modeling and simulation.  It covers a wide range of applications in the area of design, construction and operation of products, systems and services, including lifecycle development and human-technology interaction. The book describes advanced methodologies and tools for evaluating and improving interface usability, new models, as well as case studies and best practices in virtual, augmented and mixed reality systems, with a special focus on dynamic environments. It also discusses different factors concerning the human, hardware, and artificial intelligence software.