The 43 papers presented together with 7 keynote lectures were carefully reviewed and selected during two rounds of reviewing and improvement from numerous presentations at the following workshops: the 3rd Workshop on Virtualization in High-Performance Cluster and Grid Computing (VHPC 2008), the UNICORE Summit 2008, the International Workshop on Highly Parallel Processing on a Chip (HPPC 2008), the Workshop on Secure, Trusted, Manageable and Controllable Grid Services (SGS 2008), the Workshop on Productivity and Performance (PROPER 2008), the Workshop on Real-Time Online Interactive Applications on the Grid (ROIA 2008), and the Workshop on Abstractions for Distributed Systems (DPA 2008).