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Development of Micro-emulsion based formulation of Nifedipine: Solubility Enhancement by Complexation Method
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(Buch) |
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| The aim of project work was to develop Self micro-emulsified drug delivery system of nifedipine to increase the solubility in gastric environment to enhance the bioavailability. For suitable development of SMEDDS of nifedipine was studied to know the solubility in various oil, solvent and co-solvent to select the suitable oil and various components for SMEDDS formulation. Nifedipine showed the solubility in sesame oil, tween 80 and propylene glycol. solvent and co-solvent were mixed in various ratios to find the effective ratio for microemulsion formation. At least 26 were developed and only four shows the property of microemulsion which was observed by visual assessment in distilled water.Various formulations were developed and upon subjection of these trials, only trial F14 and F17 remain monophasic i.e. phase separation do not occur. Among these two trial only trial F14 show the characteristic of microemulsion i.e. showed >95 % transmittance. In that formulation oil, surfactant and co-surfactant was 4:4:2 respectively.At least three trials are carried to find the suitable ratio of various excipient in the preparation SMEDDS of nifedipine. |
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