Übersicht			Auf mobile öffnen

Lieferstatus:	Auf Bestellung (Lieferzeit unbekannt)
Veröffentlichung:	März 2018
Genre:	Naturwissensch., Medizin, Technik
	B / Biomedical and Life Sciences / Biomedical Research / Cancer Research / Immunology / Medical research / molecular biology / Molecular Medicine / Oncology
ISBN:	9783319798998
EAN-Code:	9783319798998
Verlag:	Springer Nature EN
Einband:	Kartoniert
Sprache:	English
Serie:	#393 - Current Topics in Microbiology and Immunology
Dimensionen:	H 235 mm / B 155 mm / D
Gewicht:	379 gr
Seiten:	231
Zus. Info:	Previously published in hardcover
Bewertung:	Titel bewerten / Meinung schreiben

Inhalt:

This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton's Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, whilealso paving the way for eventually combating these diseases.