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Autor(en): 
  • Ganesh Godge
  • Shivanand Hiremath
  • A Study on Solubility Enhancement Methods for Poorly Soluble Drug: New drug therapies combine antiviral to increase efficacy and to avoid the developm 
     

    (Buch)
    Dieser Artikel gilt, aufgrund seiner Grösse, beim Versand als 2 Artikel!


    Übersicht

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    Lieferstatus:   i.d.R. innert 5-10 Tagen versandfertig
    Veröffentlichung:  Juli 2014  
    Genre:  Naturwissensch., Medizin, Technik 
    ISBN:  9783659553066 
    EAN-Code: 
    9783659553066 
    Verlag:  LAP Lambert Academic Publishing 
    Einband:  Kartoniert  
    Sprache:  English  
    Dimensionen:  H 220 mm / B 150 mm / D 8 mm 
    Gewicht:  215 gr 
    Seiten:  132 
    Zus. Info:  Paperback 
    Bewertung: Titel bewerten / Meinung schreiben
    Inhalt:
    Human Immunodeficiency Virus (HIV) is a retrovirus that causes irreversible destruction of the immune system, leading to the occurrence of opportunistic infections and malignancies. During the last decade, even though attempts were being made to eradicate HIV, it was found that eradication of HIV is highly unlikely, and effective antiretroviral therapy is required on a long-term basis to maintain viral suppression and reduce disease progression. During this decade, effective therapies aimed at continued suppression of HIV replication and targeted at resting HIV reservoirs such as brain, lymphatic systems will be critical to prolong survival and renewing hopes for a cure. Most of these drugs bear some significant drawbacks such as relatively short half-life, low bioavailability, poor permeability and undesirable side effects. Efforts have been made to design drug delivery systems for antiHIV agents to: a) reduce the dosing frequency, b) increase the bioavailability and decrease the degradation in the gastrointestinal tract, c) improve the CNS penetration and inhibit the CNS efflux, and d) deliver them to the target cells selectively with minimal side effects.

      



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