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Autor(en): 
  • Venkata Srikanth Meka
  • Senthil Rajan Dharmalingam
  • Tan Wei Chie
  • A Statistical Approach to Design of Floating Drug Delivery System: Monolithic Gastric Floating Drug Delivery System of Alfuzosin 
     

    (Buch)
    Dieser Artikel gilt, aufgrund seiner Grösse, beim Versand als 2 Artikel!


    Übersicht

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    Lieferstatus:   i.d.R. innert 5-10 Tagen versandfertig
    Veröffentlichung:  August 2014  
    Genre:  Naturwissensch., Medizin, Technik 
    ISBN:  9783659583346 
    EAN-Code: 
    9783659583346 
    Verlag:  LAP Lambert Academic Publishing 
    Einband:  Kartoniert  
    Sprache:  English  
    Dimensionen:  H 220 mm / B 150 mm / D 3 mm 
    Gewicht:  96 gr 
    Seiten:  52 
    Zus. Info:  Paperback 
    Bewertung: Titel bewerten / Meinung schreiben
    Inhalt:
    This book provides a statistical approach to design and optimization of monolithic gastric floating drug delivery system of anticancer drug, Alfuzosin. Drug delivery system has its main aim to administered appropriate amount of drugs to the target site of the body in order to achieve and maintain the desired therapeutic drug concentration that elicits the desired pharmacological action. Drug absorption of oral route could be inadequate and highly variable in individuals due to physiological variabilities. This can be overcome by developing a suitable gastroretentive drug delivery system, which can prolong the gastric residence time of dosage form thereby improve the drug bio-availability. Floating drug delivery system is considerably easy and logical approach in the development of gastroretentive dosage forms. The oral delivery of anticancer alfuzosin was facilitated by preparing a gastric floating dosage form which could increase its absorption in the gastric region of the stomach by prolonging the gastric residence time of the drug. In the present work, gastric floating tablets were optimized by conventional process and further optimized by statistical methods.

      



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